The Port of Holyhead provides berthing and handling facilities for a range of commercial operations. Accordingly, a variety of vessels regularly call at the port, these include regular scheduled passenger and vehicle ferries, cruise vessels, tankers, bulk vessels, fishing vessels and military support vessels.

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Additionally a large recreational community use the sheltered harbour area with a dedicated marina hosting permanent moorings and berth facilities. The harbour has the ability to accommodate additional vessels at anchor although this is not common practice: anchoring within the fairway is prohibited and holding areas within some areas are poor.